Ras-related protein Rab-3A (Rab3a) is a 220-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P63012.
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The mean pLDDT of this model is 83.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 62% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB3A plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (PubMed:21689256). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as…
Interacts with RIMS1 and RIMS2 (By similarity) (PubMed:10748113). Interacts with Rabphilin-3A/RPH3A and Rab effector Noc2/RPH3AL (By similarity) (PubMed:10025402). Interacts with SYTL4 (By similarity). Interacts with RAB3IP (PubMed:7532276). Interacts with SGSM1 and SGSM3 (By similarity). Interacts with SYT1 (PubMed:28057568). Interacts with MYH9; this interaction is essential for lysosome…
Cytoplasm, cytosol, Lysosome, Cytoplasmic vesicle, secretory vesicle, Cell projection, axon, Cell membrane, Presynapse, Postsynapse
Compare the prediction with experimentally determined structures of the same protein:
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