Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha… (PPP2R2A) is a 447-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P63151.
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The mean pLDDT of this model is 92.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 79% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:1849734, PubMed:33108758). Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758)
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits (PubMed:38123684). Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families),…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8TWE | EM | 2.55 Å | B=2-447 |
| 9C6B | EM | 2.6 Å | B=2-447 |
| 9C7T | EM | 2.7 Å | B=2-447 |
| 8TTB | EM | 2.77 Å | B=2-447 |
| 8SO0 | EM | 2.8 Å | B=2-447 |
| 3DW8 | X-ray | 2.85 Å | B/E=1-447 |
| 9MZW | EM | 3.16 Å | B=2-447 |
| 8UO5 | EM | 3.27 Å | B=1-447 |
| 9N0Z | EM | 3.5 Å | B=2-447 |
| 9N0Y | EM | 3.71 Å | B=2-447 |
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