Leucine-rich repeat-containing protein 7 (Lrrc7) is a 1490-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P70587.
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The mean pLDDT of this model is 52.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 27% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 64% |
What pLDDT means and how to read it
Adapter protein that is required for correct postsynapse architecture and regulates postsynaptic plasticity through interactions with different partners (By similarity). Through its interaction with CACNA1C, it enhances trafficking of voltage-dependent L-type calcium channels to the dendritic cell membrane and increases channel postsynaptic clustering, thereby facilitating excitatory calcium signaling (By similarity). It also serves as a scaffold that brings CAMK2A and PPP1CA into close proximity, probably facilitating rapid dephosphorylation of CAMK2A by PPP1CA and influencing CAMK2A-mediated regulation of postsynaptic plasticity (By similarity). Necessary for DISC1 and GRM5 localization…
Interacts with CNKSR2 and DLG4 (PubMed:12390249). Interacts with CTNND2/Catenin delta-2 (By similarity). Forms a complex with N-cadherin through CTNND2 (By similarity). Interacts with CAMK2A (PubMed:10827168). Interacts with PPP1CA; the interaction may facilitate rapid CAMK2A dephosphorylation by PPP1CA by bringing CAMK2A and PPP1CA into close proximity (By similarity). Interacts with SHANK3.…
Cytoplasm, Postsynaptic density, Cell projection, dendritic spine, Postsynapse
UniProt lists no experimental PDB structure for this protein, so the AlphaFold prediction is the main 3D model available.
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