Internalin C (inlC) is a 297-residue protein from Listeria monocytogenes serotype 1/2a (strain EGD / Mackaness). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P71451.
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The mean pLDDT of this model is 92.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 88% |
| 70 to 90 | Confident: backbone generally right | 1% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
A virulence enhancer that has at least 2 dissociable functions in infection; it impairs translocation of host transcription factor NF-kappa-B to the nucleus and antagonizes the function of the Tuba dynamin-binding protein, promoting bacterial spreading (PubMed:19767742, PubMed:20855622, PubMed:24332715). Perturbs the morphology of host cell junctions by impairing host DNMBP (Tuba) and WASL interaction, altering cortical tension at the cell junctions and allowing bacteria to more efficiently form bacteria-filled cell protrusions which promote bacterial spreading within infected host tissue (PubMed:19767742, PubMed:24332715). Down-regulates the host inflammation response usually induced by…
Interacts in vitro with human intestinal mucin-2 (MUC2) but not with mucin-1; binding is slightly better at pH 5.5, (the pH of the intestine) than at pH 7.4 (PubMed:18327567). Interacts with the SH3 6 domain of human DNMBP (Tuba) (PubMed:19767742, PubMed:24332715). Interacts with I-kappa-B kinase alpha (IKKA, CHUK) (PubMed:20855622)
Secreted, Host cytoplasm
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