Interleukin-13 receptor subunit alpha-1 (IL13RA1) is a 427-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P78552.
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The mean pLDDT of this model is 81.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 56% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity
Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with IFT54. Interacts with IL4 (PubMed:18243101)
Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4HWB | X-ray | 2.61 Å | A=223-336 |
| 3BPO | X-ray | 3.0 Å | C=29-342 |
| 5E4E | X-ray | 3.0 Å | C=23-340 |
| 3BPN | X-ray | 3.02 Å | C=29-342 |
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