Cyclin-dependent kinase 5 (CDK5) is a 292-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q00535.
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The mean pLDDT of this model is 91.6 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 77% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth,…
Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Under neurotoxic stress and neuronal injury conditions, p35 is cleaved by calpain to generate p25 that hyperactivates CDK5, that becomes functionally disabled and…
Cytoplasm, Nucleus, Cell membrane, Perikaryon, Cell projection, lamellipodium, Cell projection, growth cone, Postsynaptic density, Synapse
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4AU8 | X-ray | 1.9 Å | A/B=2-292 |
| 3O0G | X-ray | 1.95 Å | A/B=1-292 |
| 7VDP | X-ray | 2.09 Å | A/B=2-292 |
| 1UNL | X-ray | 2.2 Å | A/B=1-292 |
| 1UNG | X-ray | 2.3 Å | A/B=1-292 |
| 1UNH | X-ray | 2.35 Å | A/B=1-292 |
| 7VDR | X-ray | 2.55 Å | A/B=2-292 |
| 1H4L | X-ray | 2.65 Å | A/B=1-292 |
| 7VDQ | X-ray | 2.91 Å | A/B=2-292 |
| 7VDS | X-ray | 3.05 Å | A/B=2-292 |
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