POU domain, class 5, transcription factor 1 (POU5F1) is a 360-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q01860.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 64.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 31% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 19% |
| Below 50 | Very low: often disordered regions | 44% |
What pLDDT means and how to read it
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency
Interacts with PKM (PubMed:18191611). Interacts with WWP2 (PubMed:19274063). Interacts with UBE2I and ZSCAN10 (By similarity). Interacts with PCGF1 (PubMed:26687479). Interacts with ESRRB; recruits ESRRB near the POU5F1-SOX2 element in the NANOG proximal promoter; the interaction is DNA independent (By similarity). Interacts with ZNF322 (By similarity). Interacts with MAPK8 and MAPK9; the…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7U0G | EM | 2.6 Å | K/L/M=138-290 |
| 7U0I | EM | 2.6 Å | L/M=138-292 |
| 8SPU | EM | 2.8 Å | L=138-290 |
| 8SPS | EM | 3.0 Å | L/M=138-290 |
| 6T90 | EM | 3.05 Å | K=1-360 |
| 8G8G | EM | 3.2 Å | X=1-360 |
| 8OTS | EM | 3.3 Å | K=1-273 |
| 6YOV | EM | 3.42 Å | K=1-360 |
| 9RL4 | EM | 3.5 Å | V=1-360 |
| 9RN2 | EM | 4.1 Å | V=1-360 |
| 8G8E | EM | 4.2 Å | X=1-360 |
| 9RMC | EM | 4.2 Å | V=1-360 |
| 8G8B | EM | 4.3 Å | X=1-360 |
| 8G88 | EM | 4.8 Å | X=1-360 |
| 8G87 | EM | 5.7 Å | X=1-360 |
| 9RN1 | EM | 5.9 Å | V=1-360 |
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