Inositol polyphosphate 5-phosphatase OCRL (OCRL) is a 901-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q01968.
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The mean pLDDT of this model is 82.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 59% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2 (PubMed:10764818, PubMed:15474001, PubMed:7761412, PubMed:9430698). Also, is able to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate (PubMed:15474001, PubMed:40969890, PubMed:7761412). Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes (PubMed:21971085). Involved in primary cilia assembly (PubMed:22228094,…
Interacts with APPL1, PHETA1 and PHETA2; APPL1-binding and PHETA1-binding are mutually exclusive. Interacts with clathrin heavy chain. Interacts with several Rab GTPases (in their GTP-bound forms), at least RAB1B, RAB5A, RAB6A, RAB8A, RAB31 and RAB35; these interactions may play a dual role in targeting OCRL to the specific membranes and stimulating the phosphatase activity. Interaction with…
Cytoplasmic vesicle, phagosome membrane, Early endosome membrane, Membrane, clathrin-coated pit, Cell projection, cilium, photoreceptor outer segment, Cell projection, cilium, Cytoplasmic vesicle, Endosome, Golgi apparatus, trans-Golgi network, Lysosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3QBT | X-ray | 2.0 Å | B/D/F/H=540-678 |
| 3QIS | X-ray | 2.3 Å | A=536-901 |
| 2QV2 | X-ray | 2.4 Å | A=564-901 |
| 4CMN | X-ray | 3.13 Å | A=215-560 |
| 2KIE | NMR | A=1-119 |
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