1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (PLCB3) is a 1234-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q01970.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 82.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 62% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37172014, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). In conjunction with OSBPL2, it may contribute to the control of…
Interacts with SHANK2 (By similarity). Interacts with LPAR2 (PubMed:15143197). Interacts with OSBPL2; the interaction inhibits PLCB3 ubiquitination and degradation (PubMed:38701954)
Cytoplasm, Membrane, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7SQ2 | X-ray | 2.6 Å | B=10-886 |
| 4QJ3 | X-ray | 3.0 Å | B=10-891 |
| 4QJ4 | X-ray | 3.3 Å | B=10-891 |
| 8EMX | EM | 3.3 Å | A=9-1234 |
| 8UQO | EM | 3.37 Å | Q=10-1234 |
| 8UQN | EM | 3.4 Å | B=10-1234 |
| 4QJ5 | X-ray | 3.41 Å | B=10-891 |
| 8EMW | EM | 3.5 Å | A=10-1234 |
| 8EMV | EM | 3.6 Å | A=10-1234 |
| 4GNK | X-ray | 4.0 Å | B/D=10-1234, E=934-1192 |
| 9Y7H | EM | 4.4 Å | A=10-882 |
| 9YAP | EM | 4.5 Å | A=10-882 |
| 9YAO | EM | 7.0 Å | A=10-882 |
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