Eukaryotic translation initiation factor 3 subunit G (TIF35) is a 274-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q04067.
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The mean pLDDT of this model is 77.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 34% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). Binds to the 18S rRNA but non-specifically (PubMed:10085088)
The eukaryotic translation initiation factor 3 (eIF-3) core complex is composed of TIF32, PRT1, NIP1, TIF34 and TIF35. The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4U1E | X-ray | 2.0 Å | G=1-135 |
| 8CAH | EM | 3.0 Å | r=1-274 |
| 6FYX | EM | 3.05 Å | r=1-274 |
| 6FYY | EM | 3.05 Å | r=1-274 |
| 8CAS | EM | 3.3 Å | r=1-274 |
| 3JAP | EM | 4.9 Å | s=45-96 |
| 6GSM | EM | 5.15 Å | r=48-96 |
| 6ZCE | EM | 5.3 Å | r=1-274 |
| 6GSN | EM | 5.75 Å | r=48-96 |
| 6ZU9 | EM | 6.2 Å | r=1-135 |
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