Outer kinetochore KNL1 complex subunit KRE28 (KRE28) is a 385-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q04431.
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The mean pLDDT of this model is 69.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 7% |
| 70 to 90 | Confident: backbone generally right | 49% |
| 50 to 70 | Low: treat with caution | 29% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Acts as a component of the outer kinetochore KNL1 complex that facilitates microtubule-kinetochore interactions and the spindle assembly checkpoint (PubMed:19893618, PubMed:32997987, PubMed:35042402). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:19893618). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore,…
Component of the KNL1/SPC105 complex composed of SPC105 and KRE28 (PubMed:14565975, PubMed:19893618, PubMed:32997987, PubMed:35042402). Part of the ten-subunit outer kinetochore KMN network that includes the KNL1, MIS12 and NDC80 complexes (PubMed:32997987). Interacts with the MIS12 complex subunits MTW1 (via C-terminus) and NSL1 (via C-terminus) (PubMed:14565975, PubMed:19893618,…
Nucleus, Chromosome, centromere, kinetochore
UniProt lists no experimental PDB structure for this protein, so the AlphaFold prediction is the main 3D model available.
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