Sodium channel regulatory subunit beta-1 (SCN1B) is a 218-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q07699.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 87.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 65% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes (PubMed:40768348). Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient (PubMed:40768348). The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:14622265, PubMed:15525788, PubMed:18464934,…
Voltage-gated sodium (Nav) channel consists of an ion-conducting pore-forming alpha subunit functional on its own that is regulated by one or more beta subunits (PubMed:15525788, PubMed:21994374, PubMed:30190309, PubMed:36696443, PubMed:36823201, PubMed:40768348). Interacts with SCN1A; regulatory subunit of SCN1A/Nav1.1 (PubMed:15525788, PubMed:17928445, PubMed:21994374). Interacts with SCN3A;…
Cell membrane, Perikaryon, Cell projection, Cell projection, axon, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7W9K | EM | 2.2 Å | B=1-218 |
| 8I5Y | EM | 2.6 Å | B=1-218 |
| 21TQ | EM | 2.7 Å | B=20-192 |
| 7XVE | EM | 2.7 Å | B=1-218 |
| 8I5B | EM | 2.7 Å | B=1-218 |
| 8I5G | EM | 2.7 Å | B=1-192 |
| 8THH | EM | 2.7 Å | B=1-218 |
| 7XVF | EM | 2.8 Å | B=1-218 |
| 8G1A | EM | 2.8 Å | B=1-218 |
| 8XMM | EM | 2.89 Å | B=1-218 |
| 7W9P | EM | 2.9 Å | B=1-218 |
| 8I5X | EM | 2.9 Å | B=1-218 |
| 8S9B | EM | 2.9 Å | B=1-218 |
| 8THG | EM | 2.9 Å | B=1-218 |
| 9DK5 | EM | 2.9 Å | C=1-218 |
| 21TP | EM | 3.0 Å | B=20-192 |
| 7W9M | EM | 3.0 Å | B=1-218 |
| 7W9T | EM | 3.0 Å | B=1-218 |
| 8J4F | EM | 3.0 Å | B=1-218 |
| 7XMF | EM | 3.07 Å | B=1-218 |
Showing 20 of 36 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.