Son of sevenless homolog 1 (SOS1) is a 1333-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q07889.
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The mean pLDDT of this model is 76.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 47% |
| 70 to 90 | Confident: backbone generally right | 25% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity)
Interacts (via C-terminus) with GRB2 (via SH3 domain) (PubMed:7664271, PubMed:8493579). Forms a complex with phosphorylated MUC1 and GRB2 (via its SH3 domains) (PubMed:7664271). Interacts with phosphorylated LAT2 (PubMed:12486104). Interacts with NCK1 and NCK2 (PubMed:10026169). Part of a complex consisting of ABI1, EPS8 and SOS1 (By similarity). Interacts (Ser-1134 and Ser-1161 phosphorylated…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6V9M | X-ray | 1.65 Å | B=566-1046 |
| 6V9N | X-ray | 1.65 Å | B=566-1046 |
| 6D55 | X-ray | 1.68 Å | B=566-1046 |
| 6D56 | X-ray | 1.68 Å | B=566-1046 |
| 6D59 | X-ray | 1.7 Å | B=566-1046 |
| 6D5L | X-ray | 1.7 Å | B=566-1046 |
| 6V9L | X-ray | 1.7 Å | B=566-1046 |
| 6Y44 | X-ray | 1.71 Å | P=1155-1167 |
| 7AVL | X-ray | 1.72 Å | A/B=564-1049 |
| 6CUO | X-ray | 1.73 Å | B=566-1046 |
| 6CUR | X-ray | 1.73 Å | B=566-1046 |
| 6BVI | X-ray | 1.75 Å | B=566-1046 |
| 6BVJ | X-ray | 1.75 Å | B=566-1046 |
| 6BVL | X-ray | 1.75 Å | B=566-1046 |
| 6D5E | X-ray | 1.75 Å | B=566-1046 |
| 6D5J | X-ray | 1.75 Å | B=566-1046 |
| 6V9J | X-ray | 1.76 Å | B=566-1046 |
| 6BVK | X-ray | 1.8 Å | B=566-1046 |
| 6BVM | X-ray | 1.8 Å | B=566-1046 |
| 6D5H | X-ray | 1.8 Å | B=566-1046 |
Showing 20 of 91 experimental structures (best resolution first).
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