Rho GTPase-activating protein 1 (ARHGAP1) is a 439-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q07960.
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The mean pLDDT of this model is 82.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 53% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 15% |
What pLDDT means and how to read it
GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate
Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with BNIPL
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1TX4 | X-ray | 1.65 Å | A=234-431 |
| 6R3V | X-ray | 1.75 Å | A=1-439 |
| 1OW3 | X-ray | 1.8 Å | A=198-439 |
| 2NGR | X-ray | 1.9 Å | B=206-439 |
| 7QSC | X-ray | 1.91 Å | A/C=198-439 |
| 1RGP | X-ray | 2.0 Å | A=198-439 |
| 1GRN | X-ray | 2.1 Å | B=237-439 |
| 5M70 | X-ray | 2.2 Å | A/F=198-437 |
| 7QTM | X-ray | 2.25 Å | A/H=198-439 |
| 5M6X | X-ray | 2.4 Å | A/H=198-437 |
| 1AM4 | X-ray | 2.7 Å | A/B/C=233-431 |
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