Core-binding factor subunit beta (Cbfb) is a 187-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q08024.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 84.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 55% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3) (PubMed:12434156, PubMed:8386878, PubMed:8497254). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX (PubMed:12434156, PubMed:8386878, PubMed:8497254). The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer,…
Heterodimer with RUNX1, RUNX2 and RUNX3 (PubMed:11257229, PubMed:12434156). Interacts with COPRS (PubMed:22193545). Found in a complex with PRMT5 and RUNX1 (PubMed:22193545)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3WTS | X-ray | 2.35 Å | B/G=1-142 |
| 3WTT | X-ray | 2.35 Å | B/G=1-142 |
| 3WTU | X-ray | 2.7 Å | B/G=1-142 |
| 3WTV | X-ray | 2.7 Å | B/G=1-142 |
| 3WTY | X-ray | 2.7 Å | B/G=1-142 |
| 3WTX | X-ray | 2.8 Å | B/G=1-142 |
| 3WTW | X-ray | 2.9 Å | B/G=1-142 |
| 1IO4 | X-ray | 3.0 Å | D=1-141 |
| 1ILF | NMR | A=1-141 | |
| 2JHB | NMR | A=1-141 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.