3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D) is a 809-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q08499.
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The mean pLDDT of this model is 67.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 38% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 40% |
What pLDDT means and how to read it
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes
Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1) (By similarity). Isoform 5, isoform N3 and isoform 12 bind RACK1 via their unique N-terminus. Binds ARRB2. Interacts (via…
Apical cell membrane, Cytoplasm, Membrane, Cytoplasm, cytoskeleton, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1Y2K | X-ray | 1.36 Å | A/B=388-715 |
| 8W4R | X-ray | 1.37 Å | A/B=388-715 |
| 1Y2B | X-ray | 1.4 Å | A/B=388-715 |
| 6FDC | X-ray | 1.45 Å | A/B=380-714 |
| 6LRM | X-ray | 1.45 Å | A/B=388-715 |
| 6IMI | X-ray | 1.46 Å | A/B=388-715 |
| 6IMT | X-ray | 1.48 Å | A/B=388-715 |
| 6IMD | X-ray | 1.5 Å | A/B=388-715 |
| 6IMR | X-ray | 1.5 Å | A/B=388-715 |
| 7B9H | X-ray | 1.5 Å | A/B=380-714 |
| 7CBJ | X-ray | 1.5 Å | A/B=388-715 |
| 1XOR | X-ray | 1.54 Å | A/B=388-715 |
| 7YQF | X-ray | 1.54 Å | A/B=388-715 |
| 1XOM | X-ray | 1.55 Å | A/B=388-715 |
| 6IMB | X-ray | 1.55 Å | A/B=388-715 |
| 6IMO | X-ray | 1.55 Å | A/B=388-715 |
| 8W4Q | X-ray | 1.55 Å | A/B=388-715 |
| 8WDN | X-ray | 1.55 Å | A/B=388-715 |
| 2PW3 | X-ray | 1.56 Å | A/B=388-714 |
| 2QYN | X-ray | 1.57 Å | A/B=388-715 |
Showing 20 of 122 experimental structures (best resolution first).
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