E3 ubiquitin-protein ligase ZNRF3 (znrf3) is a 853-residue protein from Xenopus tropicalis. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q08D68.
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The mean pLDDT of this model is 52.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 14% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 64% |
What pLDDT means and how to read it
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (By similarity). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (PubMed:29769720)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4C9R | X-ray | 2.1 Å | A/C=24-191 |
| 4C8T | X-ray | 2.4 Å | A/B=24-191 |
| 4C9U | X-ray | 3.0 Å | A/C=24-191 |
| 4C8U | X-ray | 3.01 Å | A/B=24-191 |
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