Q12049: Protein THP3 (THP3)

Protein THP3 (THP3) is a 470-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q12049.

Gene
THP3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
470 residues
Mean pLDDT
68.3
Model
AF-Q12049-F1 v6
Model created
1 Aug 2025
PDB structures
2

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Model confidence (pLDDT)

The mean pLDDT of this model is 68.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT bandMeaningShare of residues
Above 90Very high: backbone and side chains are usually accurate30%
70 to 90Confident: backbone generally right29%
50 to 70Low: treat with caution7%
Below 50Very low: often disordered regions35%

What pLDDT means and how to read it

Function

Forms a complex with CSN12 that is recruited to transcribed genes and required for transcription elongation. May also be involved in pre-mRNA splicing

Subunit structure

Interacts with CSN12 and SEM1

Subcellular location

Nucleus

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB IDMethodResolutionChains and residues
7EWFX-ray2.85 ÅA=186-470
7EWMX-ray2.9 ÅA=186-470

More AlphaFold highlights

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