TNF receptor-associated factor 3 (TRAF3) is a 568-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13114.
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The mean pLDDT of this model is 87.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 71% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types (PubMed:33148796, PubMed:33608556). In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome (PubMed:25847972, PubMed:27980081). Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator,…
Homotrimer. Heterotrimer with TRAF2 and TRAF5. Interacts with LTBR/TNFRSF3, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF13C TNFRSF17/BCMA, TLR4 and EDAR. Interacts with MAP3K5, MAP3K14, TRAIP/TRIP, TDP2/TTRAP, TANK/ITRAF and IFT54. Interaction with TNFRSF5/CD40 is modulated by TANK/ITRAF, which competes for the same binding site. Interacts with TICAM1. Interacts with TRAFD1. Interacts with OTUB1,…
Cytoplasm, Endosome, Mitochondrion
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8T5P | X-ray | 2.5 Å | A/B/C/D/E/F=377-568 |
| 2GKW | X-ray | 2.7 Å | A=377-568 |
| 1FLK | X-ray | 2.8 Å | A/B=341-568 |
| 1ZMS | X-ray | 2.8 Å | A=377-568 |
| 8ZUK | EM | 2.83 Å | A/B/C/G/H/I/M/N/O/S/T/U/Y/Z/a/e/f/g/k/l/m=267-568 |
| 1L0A | X-ray | 2.9 Å | A=377-568 |
| 1FLL | X-ray | 3.5 Å | A/B=341-568 |
| 1KZZ | X-ray | 3.5 Å | A=377-568 |
| 1RF3 | X-ray | 3.5 Å | A=377-568 |
| 2ECY | NMR | A=43-101 |
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