Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) is a 446-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13137.
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The mean pLDDT of this model is 80.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 54% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing…
Dimer (PubMed:23511477). Part of a complex consisting of CALCOCO2, TAX1BP1 and MYO6 (PubMed:17635994). Interacts with MYO6 (PubMed:31371777). Interacts with GEMIN4 (PubMed:12869526). Interacts with ATG8 family members MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2 (PubMed:25771791). Interacts with ATG8 family member MAP1LC3C (PubMed:23022382). Interacts with LGALS8 (PubMed:22246324,…
Cytoplasm, perinuclear region, Cytoplasm, cytoskeleton, Cytoplasmic vesicle, autophagosome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3VVV | X-ray | 1.35 Å | A=21-141 |
| 4GXL | X-ray | 2.02 Å | B=368-381 |
| 5Z7L | X-ray | 2.02 Å | A/B=10-126 |
| 4XKL | X-ray | 2.1 Å | B/D=414-446 |
| 5Z7A | X-ray | 2.38 Å | A/B=1-126 |
| 3VVW | X-ray | 2.5 Å | A=21-141 |
| 4HAN | X-ray | 2.55 Å | C/D=372-385 |
| 7EAA | X-ray | 2.6 Å | A/B=10-141 |
| 2MXP | NMR | A=414-446 | |
| 5AAQ | NMR | A=388-446 |
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