Metastasis-associated protein MTA1 (MTA1) is a 715-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13330.
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The mean pLDDT of this model is 72.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 28% |
What pLDDT means and how to read it
Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional…
Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:16428440, PubMed:28977666, PubMed:33283408, PubMed:9885572). The exact stoichiometry of the NuRD complex is unknown, and some…
Nucleus, Cytoplasm, Nucleus envelope, Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4PBZ | X-ray | 2.15 Å | B=670-695 |
| 4PBY | X-ray | 2.5 Å | C/D=656-686 |
| 4PC0 | X-ray | 2.5 Å | C/D=670-711 |
| 6ZRD | X-ray | 2.5 Å | P/Q=677-689 |
| 6ZRC | X-ray | 2.6 Å | P/Q=677-689 |
| 6G16 | X-ray | 2.8 Å | B/D/F/H=464-546 |
| 4BKX | X-ray | 3.0 Å | A=162-335 |
| 5FXY | X-ray | 3.2 Å | B/D/F/H=464-546 |
| 5ICN | X-ray | 3.3 Å | A=162-354 |
| 7AO8 | EM | 4.5 Å | A/D=1-715 |
| 7AO9 | EM | 6.1 Å | A/D=1-715 |
| 7AOA | EM | 19.4 Å | A/D=1-715 |
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