DNA-binding protein Ikaros (IKZF1) is a 519-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13422.
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The mean pLDDT of this model is 47.8 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 27% |
| Below 50 | Very low: often disordered regions | 58% |
What pLDDT means and how to read it
Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes (PubMed:10204490). Increases normal apoptosis in adult…
Heterodimer formed by the various isoforms; this modulates transcription regulator activity (PubMed:17135265, PubMed:17934067). Heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5 (PubMed:10978333). Component of the chromatin-remodeling NuRD repressor complex which includes at least HDAC1, HDAC2, RBBP4, RBBP7, IKZF1, MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4. Interacts…
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8RQC | X-ray | 2.15 Å | B/E=141-174 |
| 8TNQ | EM | 2.41 Å | C=143-178 |
| 8TNR | EM | 2.5 Å | C=143-178 |
| 9OUK | EM | 2.69 Å | C=140-196 |
| 9Q2D | EM | 2.94 Å | A=112-196 |
| 8D7Z | EM | 3.1 Å | C=112-196 |
| 6H0F | X-ray | 3.25 Å | C/F/I/L=141-174 |
| 9Y7D | EM | 3.26 Å | C=83-196 |
| 8TNP | EM | 3.3 Å | C=143-178 |
| 8D80 | EM | 3.6 Å | C=112-196 |
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