G/T mismatch-specific thymine DNA glycosylase (TDG) is a 410-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13569.
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The mean pLDDT of this model is 70.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 42% |
What pLDDT means and how to read it
DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to…
Homodimer. Interacts with AICDA and GADD45A
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4Z47 | X-ray | 1.45 Å | A=111-308 |
| 5HF7 | X-ray | 1.54 Å | A=82-308 |
| 6U17 | X-ray | 1.55 Å | A=82-308 |
| 6U16 | X-ray | 1.6 Å | A=82-308 |
| 5FF8 | X-ray | 1.7 Å | A=82-308 |
| 5JXY | X-ray | 1.71 Å | A=111-308 |
| 4XEG | X-ray | 1.72 Å | A=111-308 |
| 4Z3A | X-ray | 1.72 Å | A=111-308 |
| 4Z7Z | X-ray | 1.83 Å | A=111-308 |
| 4Z7B | X-ray | 2.02 Å | A=111-308 |
| 1WYW | X-ray | 2.1 Å | A=112-339 |
| 2D07 | X-ray | 2.1 Å | A=112-339 |
| 5T2W | X-ray | 2.2 Å | A=82-308 |
| 6U15 | X-ray | 2.4 Å | A=82-308 |
| 5CYS | X-ray | 2.45 Å | A=111-308 |
| 4FNC | X-ray | 2.49 Å | A=111-308 |
| 4JGC | X-ray | 2.58 Å | A=111-308 |
| 2RBA | X-ray | 2.79 Å | A/B=111-308 |
| 3UFJ | X-ray | 2.97 Å | A/B=111-308 |
| 3UO7 | X-ray | 3.0 Å | A/B=111-308 |
Showing 20 of 21 experimental structures (best resolution first).
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