Interleukin-11 receptor subunit alpha (IL11RA) is a 422-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q14626.
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The mean pLDDT of this model is 81.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number
On IL11 binding, forms a multimer complex with IL6ST/gp130
Membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8QY4 | EM | 3.06 Å | B/E=1-422 |
| 6O4P | X-ray | 3.43 Å | A/B=23-363 |
| 8DPS | EM | 3.47 Å | C/F=23-319 |
| 8DPU | X-ray | 3.78 Å | C/F/I/L/O/R=23-363 |
| 8DPT | EM | 4.0 Å | C/F=23-319 |
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