Separin (ESPL1) is a 2120-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q14674.
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The mean pLDDT of this model is 75.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 26% |
| 70 to 90 | Confident: backbone generally right | 48% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms
Interacts with PTTG1. Interacts with RAD21
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9HN0 | EM | 2.8 Å | B=1-1481, B=1537-2120 |
| 7NJ1 | EM | 2.9 Å | A=1-2120 |
| 9HN4 | EM | 2.93 Å | B=1-1481, B=1537-2120 |
| 9HN5 | EM | 2.96 Å | A=1-1481, A=1537-2120 |
| 9HM7 | EM | 3.1 Å | A=1-2120 |
| 9HMA | EM | 3.3 Å | A=1-2120 |
| 9HMS | EM | 3.4 Å | C=1-1481, C=1537-2120 |
| 9HVY | EM | 3.5 Å | A=1-2120 |
| 7NJ0 | EM | 3.6 Å | A=1-2120 |
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