ER membrane protein complex subunit 2 (EMC2) is a 297-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15006.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 94.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 85% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176, PubMed:33964204). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151,…
Component of the ER membrane protein complex (EMC) (PubMed:22119785, PubMed:29242231, PubMed:32439656, PubMed:32459176, PubMed:33964204). Interacts with WNK1 (via amphipathic alpha-helix region); promoting the ER membrane protein complex assembly by preventing EMC2 ubiquitination (PubMed:33964204)
Endoplasmic reticulum membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6Y4L | X-ray | 2.2 Å | A=11-274 |
| 8J0O | EM | 3.32 Å | B=1-297 |
| 7ADO | EM | 3.39 Å | B=1-297 |
| 6WW7 | EM | 3.4 Å | B=1-297 |
| 8EOI | EM | 3.4 Å | B=3-293 |
| 8J0N | EM | 3.47 Å | B=1-297 |
| 7ADP | EM | 3.6 Å | B=1-297 |
| 8S9S | EM | 3.6 Å | 2=1-297 |
| 9ZZ6 | EM | 4.16 Å | B=1-297 |
| 6Z3W | EM | 6.4 Å | B=1-297 |
| 9C7V | EM | 6.6 Å | 2=1-297 |
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