Polycomb protein SUZ12 (SUZ12) is a 739-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15022.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 71.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 38% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 31% |
What pLDDT means and how to read it
Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8,…
Component of the PRC2 complex, which consists of the core subunits EED, EZH1 or EZH2, SUZ12, and RBBP4, and various combinations of accessory subunits including AEBP2, JARID2, PHF19, MTF2 and EPOP (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16224021, PubMed:18285464, PubMed:19026781, PubMed:29499137, PubMed:31959557). Within the…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5IJ7 | X-ray | 2.62 Å | S/T=545-725 |
| 9XZI | X-ray | 2.69 Å | A=76-545 |
| 4W2R | X-ray | 2.81 Å | S/T=545-725 |
| 6NQ3 | X-ray | 2.89 Å | B/F=76-545 |
| 5WAI | X-ray | 2.9 Å | B/F=76-545 |
| 5HYN | X-ray | 2.95 Å | C/H/M/S=558-685 |
| 5IJ8 | X-ray | 2.99 Å | S/T=545-725 |
| 7TD5 | X-ray | 2.99 Å | C/H=561-739 |
| 6B3W | X-ray | 3.05 Å | S/T=545-725 |
| 8VMI | EM | 3.1 Å | L/T=1-739 |
| 8VNV | EM | 3.1 Å | A=68-685 |
| 9C8U | EM | 3.1 Å | B=1-739 |
| 5WAK | X-ray | 3.2 Å | B=76-545 |
| 8FYH | EM | 3.4 Å | B/H=1-739 |
| 9DCH | EM | 3.4 Å | B/I=1-739 |
| 5LS6 | X-ray | 3.47 Å | C/F/I/L=558-685 |
| 6C24 | EM | 3.5 Å | A/M/Q=1-739 |
| 6WKR | EM | 3.5 Å | A=1-739 |
| 8VML | EM | 3.5 Å | A=1-739 |
| 8VNZ | EM | 3.5 Å | A=1-739 |
Showing 20 of 30 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.