Cyclin-dependent kinase 5 activator 1 (CDK5R1) is a 307-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15078.
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The mean pLDDT of this model is 72.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 19% |
| Below 50 | Very low: often disordered regions | 31% |
What pLDDT means and how to read it
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution
Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3 (PubMed:15689152, PubMed:16039528, PubMed:17671990). Only the heterodimer shows kinase activity (PubMed:15689152, PubMed:16039528, PubMed:17671990). Interacts with EPHA4 and NGEF; may mediate the activation…
Cell membrane, Cell projection, neuron projection, Nucleus, Cytoplasm, perinuclear region, Perikaryon
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3O0G | X-ray | 1.95 Å | D/E=145-293 |
| 7VDP | X-ray | 2.09 Å | C/D=100-307 |
| 1UNL | X-ray | 2.2 Å | D/E=100-307 |
| 1UNG | X-ray | 2.3 Å | D/E=100-307 |
| 1UNH | X-ray | 2.35 Å | D/E=100-307 |
| 6LDP | X-ray | 2.35 Å | A/B=298-307 |
| 7VDR | X-ray | 2.55 Å | C/D=100-307 |
| 1H4L | X-ray | 2.65 Å | D/E=147-293 |
| 7VDQ | X-ray | 2.91 Å | C/D=100-307 |
| 7VDS | X-ray | 3.05 Å | C/D=100-307 |
| 7CNG | X-ray | 3.49 Å | A/B=298-307 |
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