Transcriptional enhancer factor TEF-3 (TEAD4) is a 434-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15561.
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The mean pLDDT of this model is 75.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 47% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC…
Interacts with YAP1 and WWTR1/TAZ
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9SYN | X-ray | 1.3 Å | A=217-434 |
| 6GEI | X-ray | 1.65 Å | A=216-434 |
| 6HIK | X-ray | 1.65 Å | A=216-434 |
| 6SEN | X-ray | 1.65 Å | A/B=217-434 |
| 6GEC | X-ray | 1.7 Å | A=216-434 |
| 8A8R | X-ray | 1.7 Å | A/B=216-434 |
| 9QKQ | X-ray | 1.74 Å | A/B=217-434 |
| 6GE6 | X-ray | 1.8 Å | A=216-434 |
| 6GE3 | X-ray | 1.85 Å | A=216-434 |
| 5OAQ | X-ray | 1.95 Å | A=217-434 |
| 6GEE | X-ray | 1.96 Å | A=216-434 |
| 6GE4 | X-ray | 1.97 Å | A=216-434 |
| 8CAA | X-ray | 2.0 Å | A/B=217-434 |
| 6Q36 | X-ray | 2.01 Å | A/B=217-434 |
| 6GE5 | X-ray | 2.05 Å | A=216-434 |
| 6Q2X | X-ray | 2.1 Å | A=217-434 |
| 9SYI | X-ray | 2.1 Å | A/B=217-434 |
| 6GEG | X-ray | 2.23 Å | A=216-434 |
| 8C17 | X-ray | 2.25 Å | A=217-434 |
| 6GEK | X-ray | 2.28 Å | A/B=216-434 |
Showing 20 of 23 experimental structures (best resolution first).
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