Ubiquitin-conjugating enzyme E2 variant 2 (UBE2V2) is a 145-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15819.
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The mean pLDDT of this model is 94.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 90% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage
Heterodimer with UBE2N. Binds CHFR
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4ONL | X-ray | 1.35 Å | A=1-145 |
| 4ONM | X-ray | 1.35 Å | A=1-145 |
| 4ONN | X-ray | 1.5 Å | A=1-145 |
| 9BIV | X-ray | 1.68 Å | A=1-145 |
| 9LHJ | X-ray | 1.68 Å | C/D=1-145 |
| 8WR5 | X-ray | 1.7 Å | A=1-145 |
| 4NR3 | X-ray | 1.8 Å | A=5-145 |
| 1J7D | X-ray | 1.85 Å | A=1-145 |
| 1J74 | X-ray | 1.9 Å | A=1-145 |
| 4NRG | X-ray | 1.95 Å | A=1-145 |
| 9N1F | X-ray | 2.1 Å | C=1-145 |
| 7BBD | X-ray | 2.2 Å | A=1-145 |
| 4NRI | X-ray | 2.3 Å | A=6-145 |
| 7BBF | X-ray | 2.54 Å | B/E/H=1-145 |
| 3VON | X-ray | 3.15 Å | B/D/F/I/K/M/P/R/T/W/Y/a/d/f/h/k/m/o=6-143 |
| 5AIT | X-ray | 3.4 Å | D/G=1-145 |
| 4ORH | X-ray | 4.8 Å | A/E/I=1-145 |
| 1ZGU | NMR | A=7-145 |
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