Melanoma antigen recognized by T-cells 1 (MLANA) is a 118-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q16655.
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The mean pLDDT of this model is 63.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 13% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 44% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes
Interacts with PMEL. Interacts with GPR143
Endoplasmic reticulum membrane, Golgi apparatus, Golgi apparatus, trans-Golgi network membrane, Melanosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2GTW | X-ray | 1.55 Å | C/F=27-35 |
| 4WJ5 | X-ray | 1.65 Å | C/F=26-35 |
| 3QFD | X-ray | 1.68 Å | C/F=27-35 |
| 2GTZ | X-ray | 1.7 Å | C/F=27-35 |
| 2GT9 | X-ray | 1.75 Å | C/F=26-35 |
| 2GUO | X-ray | 1.9 Å | C/F=27-35 |
| 3L6F | X-ray | 2.1 Å | C=100-114 |
| 3MRP | X-ray | 2.1 Å | P=26-35 |
| 6TMO | X-ray | 2.1 Å | C=26-35 |
| 3MRQ | X-ray | 2.2 Å | P=26-35 |
| 9O5S | X-ray | 2.27 Å | E/J/N/P=26-35 |
| 7TR4 | X-ray | 2.3 Å | P=26-35 |
| 3MRO | X-ray | 2.35 Å | P=26-35 |
| 6D78 | X-ray | 2.35 Å | C=27-35 |
| 4JFF | X-ray | 2.43 Å | C=26-35 |
| 5E9D | X-ray | 2.51 Å | C/H=26-35 |
| 4L3E | X-ray | 2.56 Å | C=26-35 |
| 3QEQ | X-ray | 2.59 Å | C=27-35 |
| 3QDM | X-ray | 2.8 Å | C=26-35 |
| 4EUP | X-ray | 2.88 Å | C/F=27-35 |
Showing 20 of 26 experimental structures (best resolution first).
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