Histone H2A type 2-C (H2AC20) is a 129-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q16777.
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The mean pLDDT of this model is 91.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 80% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7U0G | EM | 2.6 Å | C/G=1-129 |
| 7U0I | EM | 2.6 Å | C/G=1-129 |
| 8SYP | EM | 2.6 Å | C/G=1-129 |
| 8EVI | EM | 2.64 Å | C/G=1-129 |
| 7U0J | EM | 2.7 Å | C/G=1-129 |
| 8DK5 | EM | 2.71 Å | C/G=1-129 |
| 8EVG | EM | 2.75 Å | C/G=1-129 |
| 8SPU | EM | 2.8 Å | C/G=1-129 |
| 8EVH | EM | 2.85 Å | C/G=1-129 |
| 8SPS | EM | 3.0 Å | C/G=1-129 |
| 6Y5E | EM | 3.15 Å | C=12-118, G=12-119 |
| 8EVJ | EM | 4.1 Å | C/G=1-129 |
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