Serine/threonine-protein kinase unc-51 (unc-51) is a 856-residue protein from Caenorhabditis elegans. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q23023.
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The mean pLDDT of this model is 63.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 25% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 43% |
What pLDDT means and how to read it
Protein kinase important for axonal elongation and axonal guidance (PubMed:15539493, PubMed:7958904). Functions in the CAN axons to direct both anterior and posterior migrations (PubMed:15539493). Phosphorylates both unc-14 and vab-8 (PubMed:15539493). Component of the unc-51/atg-13 complex that is probably recruited by lgg-1 to preautophagosomes and is required for autophagosome formation (PubMed:12958363, PubMed:17890369, PubMed:19377305, PubMed:26687600). Interaction with autophagy related proteins such as atg-13 links it to the autophagy machinery to in turn promote P-granule degradation in somatic cells (PubMed:19377305). Plays a role in mitophagy during limited food availability…
Interacts with unc-14 and vab-8 (PubMed:15539493). Interacts (via C-terminus) with atg-13 (PubMed:19377305). Interacts (via the LIR motif) with lgg-1; the interaction is direct (PubMed:26687600)
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5AZG | X-ray | 1.81 Å | C/D=352-361 |
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