Protein vestigial (vg) is a 453-residue protein from Drosophila melanogaster. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q26366.
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The mean pLDDT of this model is 47.4 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 4% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 76% |
What pLDDT means and how to read it
Forms a complex with sd/scalloped that acts as a transcriptional activator regulating gene expression during wing development (PubMed:11112330, PubMed:12702681, PubMed:14526388, PubMed:9799424, PubMed:9869635, PubMed:9869643). Binding to sd switches the DNA target selectivity of sd to recognize a distinct set of target enhancers (PubMed:11546746). Together with sd regulates expression of Bx/Beadex/dLMO, which in turn regulates the activity of ap/apterous involved in driving cellular proliferation and dorsoventral (D/V) boundary formation in wing imaginal discs (PubMed:12485165, PubMed:16950871). Together with sd involved in regulating cell adhesion properties involved in the separation of…
Interacts (via Ser-rich sd binding domain) with sd (via C-terminus); the interaction is direct (PubMed:12702681, PubMed:12782275, PubMed:14526388, PubMed:33060790, PubMed:9799424, PubMed:9869635, PubMed:9869643). Interacts with Dhfr (PubMed:14526388)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6Y20 | X-ray | 1.85 Å | C/D=298-337 |
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