Inverted formin-2 (INF2) is a 1249-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q27J81.
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The mean pLDDT of this model is 66.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 29% |
| 70 to 90 | Confident: backbone generally right | 25% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 39% |
What pLDDT means and how to read it
Severs actin filaments and accelerates their polymerization and depolymerization
Interacts with actin at the FH2 domain. Interacts with DAAM2 (PubMed:33232676)
Cytoplasm, perinuclear region
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9B03 | EM | 2.95 Å | G/H=551-987 |
| 9B0K | EM | 3.03 Å | G/H=551-987 |
| 9AZ4 | EM | 3.37 Å | G/H=551-987 |
| 8RV2 | EM | 3.41 Å | E/F=469-1235 |
| 9AZP | EM | 3.79 Å | G/H=1-1249 |
| 9AZQ | EM | 3.82 Å | G=551-610, H=625-947 |
| 9FJN | NMR | A=2-19 | |
| 9FJW | NMR | A=2-36 | |
| 9G7T | NMR | A=967-991 | |
| 9RWF | NMR | A=967-991 |
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