Staphylococcal superantigen-like 3 (ssl3) is a 356-residue protein from Staphylococcus aureus (strain NCTC 8325 / PS 47). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q2G0X7.
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The mean pLDDT of this model is 69.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 51% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 45% |
What pLDDT means and how to read it
Secreted protein that plays an essential role in immune innate response inhibition by interacting with and inhibiting host TLR2. In turn, bacteria recognition by immune cells is impaired and cytokine production is inhibited (PubMed:22665377, PubMed:22714643). Mechanistically, by interacting with TLR2, blocks ligand binding and thus inhibits activation (PubMed:26283364). Second, by interacting with an already formed TLR2-lipopeptide complex, prevents TLR heterodimerization and downstream signaling. The interaction with host TLR2 does not involve sialyl Lewis X interactions (PubMed:26283364)
Interacts with host TLR2 (via its extracellular domain)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5I4D | X-ray | 1.75 Å | A/B=31-356 |
| 5D3D | X-ray | 1.94 Å | A/B=164-356 |
| 5D3I | X-ray | 3.2 Å | B=164-356 |
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