Synaptic vesicle glycoprotein 2C (SV2C) is a 727-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q496J9.
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The mean pLDDT of this model is 78.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 33% |
| 70 to 90 | Confident: backbone generally right | 42% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles
Interacts with SYT1 in a calcium-dependent manner
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5JLV | X-ray | 2.0 Å | C/D=473-567 |
| 6ES1 | X-ray | 2.0 Å | B=474-567 |
| 4JRA | X-ray | 2.3 Å | C/D=456-574 |
| 5MOY | X-ray | 2.3 Å | B=456-574 |
| 7UIA | X-ray | 2.59 Å | C/F=473-568 |
| 7UIB | X-ray | 2.77 Å | C/F=473-568 |
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