Cytokine-like nuclear factor N-PAC (GLYR1) is a 553-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q49A26.
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The mean pLDDT of this model is 77.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 28% |
What pLDDT means and how to read it
Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984, PubMed:30970244). Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (PubMed:20850016, PubMed:30970244). Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes…
Homotetramere (PubMed:30970244, PubMed:31408337). Interacts with MAPK14 (PubMed:16352664). Interacts with KDM1B at nucleosomes; this interaction stimulates H3K4me1 and H3K4me2 demethylation (PubMed:23260659). Binds to mononucleosomes (PubMed:29759984). Interacts with GATA4; the interaction is required for a synergistic activation of GATA4 target genes transcription (PubMed:35182466)
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4HSU | X-ray | 1.99 Å | B=152-268 |
| 4GUT | X-ray | 2.0 Å | B=152-268 |
| 4GUS | X-ray | 2.23 Å | B=152-268 |
| 4GUU | X-ray | 2.3 Å | B=152-268 |
| 2UYY | X-ray | 2.5 Å | A/B/C/D=261-553 |
| 4GUR | X-ray | 2.51 Å | B=152-268 |
| 6R1U | EM | 4.36 Å | L=152-268 |
| 6R25 | EM | 4.61 Å | L=214-225 |
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