Histone-lysine N-methyltransferase KMT5B (KMT5B) is a 885-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q4FZB7.
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The mean pLDDT of this model is 54.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 21% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 64% |
What pLDDT means and how to read it
Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these…
Homodimer (PubMed:24396869, Ref.14). Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2 (By similarity). Interacts (via C-terminus) with FRG1
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3S8P | X-ray | 1.85 Å | A/B=63-335 |
| 8T68 | X-ray | 1.9 Å | A=62-335 |
| 5CPR | X-ray | 2.22 Å | B=69-335 |
| 5WBV | X-ray | 2.3 Å | A/B=63-335 |
| 8T9F | EM | 2.6 Å | K=1-392 |
| 7YRD | EM | 3.2 Å | K=62-363 |
| 8T9H | EM | 3.37 Å | K=2-392 |
| 8JHG | EM | 3.58 Å | K=1-361 |
| 8JHF | EM | 3.68 Å | K=1-361 |
| 7YRG | EM | 4.2 Å | K/L=62-363 |
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