Taperin (TPRN) is a 711-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q4KMQ1.
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The mean pLDDT of this model is 54.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 2% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 28% |
| Below 50 | Very low: often disordered regions | 52% |
What pLDDT means and how to read it
Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405)
Interacts with GRXCR2; the interaction restricts TPRN to the stereocilum basal region (By similarity). Interacts with actin ACTB; the interaction may stabilize stereocilia (By similarity). Interacts with CLIC5 (PubMed:24285636). Interacts with PTPRQ (By similarity). TPRN, CLIC5 and PTPQR form concentric rings at the base of stereocilia and may form a complex (By similarity). Interacts with…
Cell projection, stereocilium, Cell projection, microvillus, Nucleus, nucleoplasm, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6Y9Q | X-ray | 1.31 Å | D=452-468 |
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