Angiomotin (AMOT) is a 1084-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q4VCS5.
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The mean pLDDT of this model is 56.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 23% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 60% |
What pLDDT means and how to read it
Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866)
Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3 (PubMed:16678097). Interacts with MAGI1 (PubMed:16043488)
Cell junction, tight junction
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7NP2 | X-ray | 1.27 Å | P=169-188 |
| 7OQS | X-ray | 1.34 Å | P=169-181 |
| 7NPB | X-ray | 1.37 Å | P=169-188 |
| 7NPG | X-ray | 1.37 Å | P=169-188 |
| 7NND | X-ray | 1.4 Å | P=169-181 |
| 7OQJ | X-ray | 1.4 Å | P=169-181 |
| 7OQU | X-ray | 1.4 Å | P=169-181 |
| 7NMW | X-ray | 1.5 Å | P=169-181 |
| 7OQG | X-ray | 1.5 Å | P=169-181 |
| 7LP3 | X-ray | 1.61 Å | B/D=234-247 |
| 7NMA | X-ray | 1.75 Å | P=169-181 |
| 7NN2 | X-ray | 1.8 Å | P=169-181 |
| 7LP2 | X-ray | 1.88 Å | B/D/F=233-247 |
| 7OQW | X-ray | 1.9 Å | P=169-181 |
| 7NNE | X-ray | 1.96 Å | P=169-181 |
| 6JJX | X-ray | 2.0 Å | C/D=272-293 |
| 7NMX | X-ray | 2.3 Å | P=169-181 |
| 7LP5 | NMR | A=100-114 |
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