DNA annealing helicase and endonuclease ZRANB3 (ZRANB3) is a 1079-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q5FWF4.
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The mean pLDDT of this model is 72.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 30% |
| 70 to 90 | Confident: backbone generally right | 39% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634, PubMed:28621305). In addition to endonuclease…
Interacts (via PIP-box, APIM motif and RanBP2-type zinc finger) with PCNA (when PCNA is polyubiquitinated via 'Lys-63'-linked polyubiquitin); the interaction stimulates ZRANB3 endonuclease activity and is required for ZRANB3 recruitment to DNA replication sites
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5MLO | X-ray | 1.96 Å | B/D/F=515-529 |
| 5MKW | X-ray | 2.0 Å | A/B=948-1067 |
| 5YD8 | X-ray | 2.3 Å | U/V/W=1069-1079 |
| 5MLW | X-ray | 2.45 Å | B/D/F=1069-1079 |
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