IQ motif and SEC7 domain-containing protein 2 (IQSEC2) is a 1488-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q5JU85.
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The mean pLDDT of this model is 53.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 21% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 63% |
What pLDDT means and how to read it
Is a guanine nucleotide exchange factor (GEF) for small GTPases of the ARF family, promoting activation of specific ARFs through exchange of GDP for GTP (PubMed:26793055, PubMed:37787765). In vitro, it has GEF activity towards ARF1 and ARF6 (PubMed:30842726, PubMed:37787765, PubMed:38200111). Is involved in the regulation of synaptic transmission and plasticity, controlling trafficking and removal of AMPA receptors GRIA2/GLUA2 and GRIA3/GLUA3 at synapses (PubMed:27009485, PubMed:30842726). Additionally, it may regulate the assembly of the post-synaptic density in a Ca(2+)-dependent manner, operating independently of its GEF activity (PubMed:41123449)
Interacts (via C-terminus) with DLG4/PSD95 (PubMed:27009485, PubMed:41123449). Interacts with calmodulin (CALM1); under resting conditions the interaction with CALM1 blocks the ARFs binding site and keeps IQSEC2 in an inactive state (PubMed:37787765, PubMed:41123449)
Cell projection, dendritic spine, Postsynaptic density
Compare the prediction with experimentally determined structures of the same protein:
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