WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) is a 344-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q5MNZ6.
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The mean pLDDT of this model is 94.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 90% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2 (PubMed:28561066, PubMed:30797857). In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the…
Interacts with the TSC1-TSC2 complex; stimulated upon starvation (PubMed:28561066). Interacts with RB1CC1 (PubMed:28561066). Interacts with ATG2A (PubMed:32483132)
Preautophagosomal structure, Lysosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6IYY | X-ray | 1.8 Å | A=8-344 |
| 6KLR | X-ray | 2.21 Å | A/B=8-344 |
| 8ZQG | X-ray | 2.77 Å | A/B=8-344 |
| 9CE3 | EM | 2.9 Å | F=12-344 |
| 9C9I | X-ray | 3.18 Å | A/C/E/G=12-344 |
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