E3 ubiquitin-protein ligase ZNRF3 (Znrf3) is a 913-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q5SSZ7.
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The mean pLDDT of this model is 51.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 12% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 67% |
What pLDDT means and how to read it
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone (PubMed:22575959, PubMed:22895187). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity)
Interacts with LRP6, FZD4, FZD5, FZD6 and FZD8 (By similarity). Interacts with RSPO1; interaction promotes indirect interaction with LGR4 and membrane clearance of ZNRF3 (By similarity). Interacts with LMBR1L (PubMed:31073040)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4CDJ | X-ray | 1.5 Å | A/B=53-205 |
| 4C86 | X-ray | 2.0 Å | A/B=53-205 |
| 4C8P | X-ray | 2.1 Å | A=53-205 |
| 4C8C | X-ray | 2.4 Å | A/B=53-205 |
| 4C9A | X-ray | 2.4 Å | A/C=53-205 |
| 4C8F | X-ray | 2.69 Å | A/B/C/D=53-205 |
| 4C8A | X-ray | 2.7 Å | A/B/C=53-205 |
| 4C99 | X-ray | 2.8 Å | A/C=53-205 |
| 4CDK | X-ray | 2.8 Å | A/B/C/D=53-205 |
| 4C9E | X-ray | 3.0 Å | A/C/E/G=53-205 |
| 4UFS | X-ray | 4.8 Å | C=53-205 |
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