Calmodulin-regulated spectrin-associated protein 1 (CAMSAP1) is a 1602-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q5T5Y3.
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The mean pLDDT of this model is 54.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 19% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 62% |
What pLDDT means and how to read it
Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the…
Interacts with spectrin via SPTBN1; the interaction is direct (PubMed:24117850). Interacts with calmodulin; calcium-dependent it prevents interaction with spectrin (PubMed:24117850)
Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6QUS | EM | 3.7 Å | I=1462-1602 |
| 6QVJ | EM | 3.8 Å | I=1462-1602 |
| 5M5C | EM | 4.8 Å | C=1472-1589 |
| 5M54 | EM | 8.0 Å | C=1473-1589 |
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