Q5UCC4: ER membrane protein complex subunit 10 (EMC10)

ER membrane protein complex subunit 10 (EMC10) is a 262-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q5UCC4.

Gene: EMC10
Organism: Homo sapiens
Length: 262 residues
Mean pLDDT: 77.6
Model: AF-Q5UCC4-F1 v6
Model created: 1 Aug 2025
PDB structures: 10

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Model confidence (pLDDT)

The mean pLDDT of this model is 77.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT band	Meaning	Share of residues
Above 90	Very high: backbone and side chains are usually accurate	50%
70 to 90	Confident: backbone generally right	16%
50 to 70	Low: treat with caution	16%
Below 50	Very low: often disordered regions	18%

What pLDDT means and how to read it

Function

Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also…

Subunit structure

Component of the ER membrane protein complex (EMC)

Subcellular location

Endoplasmic reticulum membrane, Secreted

Disease associations

Neurodevelopmental disorder with dysmorphic facies and variable seizures (NEDDFAS)

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB ID	Method	Resolution	Chains and residues
8J0O	EM	3.32 Å	J=1-207
7ADO	EM	3.39 Å	I=2-262
6WW7	EM	3.4 Å	I=1-262
8EOI	EM	3.4 Å	I=50-206
8J0N	EM	3.47 Å	J=1-207
7ADP	EM	3.6 Å	I=2-262
8S9S	EM	3.6 Å	10=1-262
9ZZ6	EM	4.16 Å	I=1-262
6Z3W	EM	6.4 Å	I=1-262
9C7V	EM	6.6 Å	10=1-262

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