Lufaxin is a 301-residue protein from Lutzomyia longipalpis. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q5WPU8.
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The mean pLDDT of this model is 85.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 63% |
| 70 to 90 | Confident: backbone generally right | 25% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Sand fly salivary protein with antithrombotic, and anti-complement (alternative pathway) activities (PubMed:22796577, PubMed:28912782, PubMed:36947859). Is a slow, tight, non-competitive, and reversible inhibitor of factor Xa (FXa, F10) (PubMed:22796577). Is specific for FXa (Kd=3.86 nM) and does not interact with non-activated FX, or all other enzymes tested (PubMed:22796577). In addition, it blocks prothrombinase and increases both prothrombin time and activated partial thromboplastin time (PubMed:22796577). It also prevents protease-activated receptor 2 (F2RL1, PAR2) activation by FXa (PubMed:22796577). In vivo, it abrogates edema formation triggered by injection of FXa in the paw of…
Interacts with factor Xa (PubMed:22796577, PubMed:36947859). Associates with complement proconvertase C3b-B complex (PubMed:28912782, PubMed:36947859)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8EO2 | X-ray | 2.31 Å | A/B=24-301 |
| 8ENU | EM | 3.22 Å | A=24-301 |
| 8EOK | EM | 3.53 Å | A=24-301 |
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