Salivary anti-complement protein is a 115-residue protein from Lutzomyia longipalpis. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q5WPZ4.
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The mean pLDDT of this model is 81.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 19% |
What pLDDT means and how to read it
Salivary protein that inhibits the classical pathway of complement system activation in the host while having no inhibitory effect on the alternative or lectin pathways (PubMed:26758086, PubMed:28278244). Prevent cleavage of host C4 and consequently impairs the activation of factors downstream of C4b in the complement cascade (PubMed:26758086)
May form multimers
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5KX4 | X-ray | 1.94 Å | A/B=23-115 |
| 9EKE | X-ray | 3.1 Å | A/B=23-115 |
| 9EKD | X-ray | 3.28 Å | A/B=23-115 |
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