Voltage-gated delayed rectifier potassium channel KCNH1 (Kcnh1) is a 989-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q60603.
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The mean pLDDT of this model is 73.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 41% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate (PubMed:19671703, PubMed:23975098). The activation kinetics depend on the prepulse potential and external divalent cation concentration. With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation. The time course of activation is biphasic with a fast and a slowly activating current component. Activates at more positive membrane potentials and exhibit a steeper activation curve (By similarity).…
Homomultimer (By similarity). The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits (PubMed:23555008, PubMed:23975098). Heteromultimer with KCNH5/EAG2 (By similarity). Interacts with ALG10B (By similarity). Interacts with RABEP1 (PubMed:22841712). Interacts (via C-terminus) with CTTN. Interacts…
Cell membrane, Nucleus inner membrane, Cell projection, dendrite, Cell projection, axon, Presynaptic cell membrane, Perikaryon, Postsynaptic density membrane, Early endosome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4HOI | X-ray | 1.85 Å | A/B/C/D=28-137 |
| 4LLO | X-ray | 2.0 Å | A/C/E/G=552-724, B/D/F/H=6-136 |
| 4F8A | X-ray | 2.2 Å | A=552-707 |
| 5HIT | X-ray | 2.85 Å | B=727-743 |
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